Insulin potentiation therapy (IPT) is an emerging therapeutic modality used to treat cancer and other diseases, using insulin in combination with other drugs, including chemotherapy agents.

IPT dates from about 1930, and has been in use continuously since by a small, but now rapidly growing number of doctors. Currently more than 100 physicians in 22 countries have IPT certification.

Dr. Szulc is the only physician in New York City currently offering IPT.

Cancer is one of the most successful applications of insulin potentiation therapy (IPT). This method was first used to treat cancer in 1945, by Dr. Perez Garcia I, and has been used with very good results by all the IPT doctors since.

1. Insulin makes cell membranes more permeable, so drugs can be transported and delivered more effectively.

2. There are many more insulin receptors on typical cancer cells, so more drug concentration is delivered to them.

3. Insulin stimulates cancer cells to begin to divide, making them more vulnerable to many chemotherapy drugs.

4. Possible stimulation of immune function and elimination of toxins.

5. Poorly-understood improvements of blood chemistry that favor healing and discourage cancer.

In basic terms, since the treatment makes the delivery of chemotherapy more effective, a lesser dosage is required for a similar effective dosage of regular chemotherapy, which bombards the body with high doses to get through to the cancer.

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1. A small amount of insulin is injected intravenously.|
2. Over 18 to 40 minutes, symptoms of mild hypoglycemia develop.
3. At the "therapeutic moment", medications are injected intravenously, together with or followed by intravenous glucose, ending the hypoglycemia.

IPT consists of an artificially generated pulse of hypoglycemia (low blood sugar) that apparently improves the effectiveness of drugs through several mechanisms. IPT makes cell membranes more permeable, and increases uptake of drugs into cells. It apparently makes tissues more permeable, too. It can help transport drugs across the blood-brain barrier. It may stimulate growth of blood vessels, and may stimulate and balance the immune system. In tumors, it apparently selectively delivers chemotherapy drugs to cancer cells, and makes the cells more susceptible to the drugs by modifying their metabolism and by stimulating them to begin dividing. IPT also may change the chemistry of the blood in a way that appears to improve health.

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1. The patient shows up for treatment having fasted overnight. A tray of medications is prepared, based on the patient's illness, symptoms, and general condition. Doses are typically 1/2 to 1/20 of the dose normally given without IPT.

2. An intravenous (IV) drip is established. A small amount of IV insulin is given, about 0.1 to 0.4 units per kilogram of patient weight. Humalog (Lilly, fast-acting human-like insulin) is the current insulin of choice. Humulin (Lilly, regular human insulin) is also very effective. Any intramuscular and oral medications are given to the patient a few minutes later, so that they will have time to enter the bloodstream. The patient is always under close observation. In a rare case of insulin hypersensitivity, IV glucose can be immediately given to avoid any danger of shock.

3. After 20 to 30 minutes, symptoms of mild hypoglycemia (low blood sugar) start to develop: hunger, thirst, drowsiness, mild sweat, increased body temperature, faster heartbeat (tachycardia) and palpitations. The doctor decides how long to wait, and how far these symptoms should progress. Deeper hypoglycemia seems to produce quicker and more profound medical results. Normal blood glucose ranges from 80 to 100 mg/dl. During IPT, it falls to around 55 to 60 mg/dl. Using Humulin (human insulin of recombinant DNA origin, Lilly), the process takes roughly 29 to 42 minutes. Using Humalog (faster acting variant of Humulin), it takes only 18 to 21 minutes.

4. The "Therapeutic Moment" has arrived. The Drs. Donato say that at this time, "the doors are open", and medications can be most effectively absorbed. Intravenous medications are given, followed by IV hypertonic glucose. Symptoms of hypoglycemia rapidly disappear. And the patient is given a sweet beverage (Gatorade or fruit juice) to complete the recovery of normal blood sugar levels. Total elapsed time for the IPT treatment (using Humalog) can be less than 90 minutes.

5. The patient is sent away with specific instructions on what light meals to eat, and sometimes with oral medications to take between treatments. Another treatment may be given in two days to two months, depending on the patient's condition and stage of treatment.

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The History of IPT

IPT was discovered in 1926-28, with the emergence of Insulin as a medical instrument, by Donato Perez Garcia, M.D., and developed by him in Mexico City during the 1930s and 1940s. He called the treatement cellular therapy or Donatian therapy or cellular therapy for the change of the physicochemical constants of the blood. His son Donato Perez Garcia y Bellón, M.D. II joined him in 1956 and both demonstrated astounding successes in their private practice, stirring interest among the medical community.

Dr. Perez Garcia I then tried this protocol in human syphilis patients in 1928 with amazing success. He could successfully treat an otherwise incurable common disease. He found that he could actually use larger doses of the toxic mercury and arsenic drugs, not only getting them into the CNS, but also getting them out of the body afterwards. He also began to try this insulin potentiation method for treatment of other diseases, again with remarkable success. It would not be until the biochemical and molecular biological understandings of the 1970s and 1980s that some of the mechanisms of insulin potentiation would be understood.

Since then, IPT has emerged and many other physicians have embraced the method including Steven G. Ayre, M.D and Jean-Claude Paquette, M.D.

IPT is now emerging as one of the most exciting and promising modalities in a current climate open-minded to the benefits of "alternative" or progressive medicine.

For more information on IPT go to IPTQ.com

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